It is recommended as one of the second-line options in patients who are refractory or intolerant to first-line hydroxycarbamide. We comply with the HONcode standard for trustworthy health information -. Follicular Lymphoma 4. Of these, IFN-α2 and IFN-α14 are glycosylated. Interferon alfa-2b is also sometimes used to treat hepatitis D virus (HDV; swelling of the liver caused by a virus), basal cell carcinoma (a type of skin cancer), cutaneous T-cell lymphomas (CTCL, a type of skin cancer), and kidney cancer. Interferon alfa stimulates T cells and other immune system cells to attack the cancer. Feeling tired or weak. By subcutaneous injection. Tell your doctor about the allergy and Do not flush down a toilet or pour down a drain unless you are told to do so. This may lead to a higher chance of getting an infection. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Interferon beta has 30% amino-acid homology with interferon alpha but only 1% homology with interferon gamma. If intolerance persists after dose adjustment or if granulocytes decrease to <250/mm3 or ALT/AST rises to >10xupper limit of normal, discontinue interferon alfa-2b therapy. Contraindications. Fatigue (8-96%) Fever (34-94%) Neutropenia (92%) Flu-like syndrome (79%) Myalgia (28-75%) Anorexia (1-69%) Leukopenia (68%) Nausea (17-66%) Transaminases increased (13-63%) Weakness (63%) Headache (21-62%) Chills (54%) Diarrhea (2-45%) Rigors (42%) Depression (up to 40% of pts), suicidal ideation/ attempts, suicide Alopecia (38%) Dyspnea (34%) Somnolence (33%) Vomiting (2-32%) Anemia (32%) Cough (31%) Pharyngitis (31%) Chest pain (28%) Xerostomia (28%) Rash (25%) Dizziness (24%) Taste al… Interferon alpha (Roferon-A ®) is used to treat: . These include headache, weakness, fever, shakes, aches, pains, and sweating. Tell your doctor if you are pregnant or plan on getting pregnant. It may be given to you for other reasons. That … Talk with the doctor. https://www.webmd.com/drugs/2/drug-76111/ribavirin-interferon-alfa-2b/details Cautions. Interferon alfa is used for intralesional treatment of external anogenital warts and condyloma acuminatum. Sometimes, these may be deadly. However, many people have no side effects or only have minor side effects. The individual interferon alpha proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156 - 172 amino acids (aa). Two types of interferon are FDA-approved as adjuvant treatment for patients with high-risk melanoma: Interferon alfa-2b (Intron A) and peginterferon alfa-2b (Sylatron). taken, how much, and when it happened. REBETOL (ribavirin, USP) Capsules is indicated in combination with INTRON A (interferon alfa-2b, recombinant) Injection for the treatment of chronic hepatitis C in patients with compensated liver disease previously untreated with alpha interferon or who have relapsed following alpha interferon therapy. Roferon-A (interferon alfa-2a, recombinant) is indicated for the treatment of chronic hepatitis C and hairy cell leukemia in patients 18 years of age or older. Induction of early regression of life-threatening corticosteroid resistant haemangiomata of infancy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Interferon alfa-2b is a prescription medication used to treat chronic hepatitis B, chronic hepatitis C, certain type of genital warts, hairy cell leukemia, malignant melanoma, AIDS-related Kaposi's sarcoma, and follicular lymphoma.. Interferon alfa-2b belongs to a group of drugs called interferons. Alpha interferons may cause mental health problems or make them worse. 1994 Dec;21(16):2853-8. Long-term outcome of interferon-alpha-induced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment. Call your doctor for medical If your symptoms or health problems do not get better or if they become worse, call your doctor. Contraindications. Signs of liver problems like dark urine, feeling tired, not hungry. The use of interferon alfa-2b for the treatment of West Nile virus is suggested by in vitro data only. Tell all of your health care providers that you take interferon alfa-n3. advice about side effects. Throw syringe away after use. Unlicensed use. Last updated on Aug 21, 2020. Check your blood sugar as you have been told by your doctor. It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. Diarrhea . There may be drug take-back programs in your area. Generic Name: Interferon Alfa-2a (in ter FEER on AL fa too aye). Keep all drugs out of the reach of children and pets. Intron A Description. Low white blood cell counts have rarely happened with interferon alfa-n3. Cavalheiro et al. Indications and dose. Pegylated interferon alfa-2b, sold under the brand name PegIntron among others, is a medication used to treat hepatitis C and melanoma. Interferon alpha contains a mixture of several proteins, all with structural, serological, and functional properties typical for natural interferon alpha (IFN-α). pharmacist if you have questions about the best way to throw out drugs. Avoid driving and doing other tasks or actions that call for you to be alert until you see how interferon alfa-2a affects you. Tell your doctor about the allergy and Serious and severe bacterial infections, some fatal and some not associated with neutropenia, have been observed in patients treated with alpha interferons. Talk to your doctor about the risks of using this medication for your condition. Suicide or suicidal thoughts, thoughts of hurting others, Interferon alpha is the generic name for the trade name drugs Intron® A, Roferon®-A. Medically reviewed by Drugs.com. of Microbiology, Kyoto Prefectural University of Medicine. Signs of an allergic reaction, like rash; Low white blood cell counts have rarely happened with interferon alfa-n3. [Interferon-alpha, beta, gamma] Gan To Kagaku Ryoho. Interferon alfa-2b is also sometimes used to treat hepatitis D virus (HDV; swelling of the liver caused by a virus), basal cell carcinoma (a type of skin cancer), cutaneous T-cell lymphomas (CTCL, a type of skin cancer), and kidney cancer. to make sure that it is safe for you to take interferon alfa-n3 with all of your drugs and health problems. Description of Clinical Studies a type of damage to the eye from diabetes. BMJ Case Rep 2017; 2017. Follow all instructions closely. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Hebero… risks and side effects that may happen. This medicine is colorless to a faint yellow. If you have any of these health problems: Kidney disease or. Hairy cell leukemia 5. Interferon-alpha (or interferon-alfa) Interferon-beta; Interferon-gamma; Cells that have been infected with viruses or other germs give off interferon-alpha and interferon-beta as … Condyloma Acuminatum 3. Talk with a doctor or pharmacist if you have any questions. high amount of triglyceride in the blood. with your doctor, nurse, pharmacist, or other health care provider. Use birth control that you can trust to prevent pregnancy while taking interferon alfa-2a. Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. Do not share your drugs with others and do not take anyone else's drugs. DESCRIPTION. Ribavirin combined with interferon alfa-2b, interferon alfacon-1 (Infergen), pegylated interferon alfa-2b, or pegylated interferon alpha-2a, all are approved for the treatment of chronic hepatitis C. interferon beta-1b (Betaseron) and interferon beta-1a (Avonex) are approved for the treatment of multiple sclerosis. It is used to treat hepatitis B and C infections. Interferon alfa is well absorbed following IM or subcutaneous injection; the apparent fraction of the dose absorbed after IM or subcutaneous injection exceeds 80%. The use of Interferon Alpha-2B Recombinant "prevents aggravation and complications in patients reaching that stage that ultimately can result in … Do not share needles or other things like toothbrushes or razors. Wash hands often. REBETOL (ribavirin, USP) Capsules is indicated in combination with INTRON A (interferon alfa-2b, recombinant) Injection for the treatment of chronic hepatitis C in patients with compensated liver disease previously untreated with alpha interferon or who have relapsed following alpha interferon therapy. Not hungry. There may be drug take-back programs in your area. You will need to talk about the benefits and risks of using interferon alfa-2a This medicine may be used with other drugs to treat your health condition. Generic Name : Interferon Alfa 2A Pronunciation : IN-ter-FEER-on ALfa Latest prescription information about Interferon Alfa 2A. Interferons are named for their ability to "int any drug without checking with your doctor. Do not share your drugs with others and do not take anyone else's drugs. a type of damage to the eye from diabetes. Adults. Do not have any kind of [Article in Japanese] Author J Imanishi 1 Affiliation 1 Dept. Interferon alfa-2a acts similarly to native interferon alpha. 4 Interferon alfa-2b, 5 recombinant 6 For Injection 7 8 WARNING 9 Alpha interferons, including INTRON® A, cause or aggravate fatal or life-threatening 10 neuropsychiatric, autoimmune, ischemic, and infectious disorders. Be ready to tell or show what was This medication is used to treat various cancers (e.g., leukemia, melanoma, AIDS-related Kaposi's sarcoma). It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. In one of the initial studies, all 19 patients receiving intracystic interferon-alpha showed reduction in tumor size with a mean initial volume 33.50 cm 3 and mean final tumor volume of 3.10 cm 3. The combination of peginterferon alfa and ribavirin should be used for treating moderate to severe chronic hepatitis C in patients aged over 18 years: Do not give to a child younger than 3 years of age. Do not use if the solution is cloudy, leaking, or has particles. Interferon alpha-1/13 is a protein that in humans is encoded by the IFNA1 gene. Fatigue (24% to 67% ) Headache (27% to 54% ) Fever (24% to 54% ) Myalgia (26% to 51% ) Influenza-like illness (25% to 47% ) Rigor (25% to 47% ) Neutropenia (21% to 40% ) Anxiety (19% to 33% ) Feeling nervous (19% to 33% ) Irritability (19% to 33% ) Diarrhea (11% to 31% ) Injection site inflammation (10% to 31% ) Insomnia (19% to 30% ) Arthralgia (22% to 28% ) Alopecia (18% to 28% ) Abdominal pain (8% to 26% ) Nausea and vomiting (5% to … increased thirst tiredness urinating more often than normal increased appetite weight loss your breath smells like fruit If your symptoms or health problems do not get better or if they become worse, call your doctor. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Keep all drugs out of the reach of children and pets. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. It can also encourage cancer cells to send out chemicals that attract immune system cells to them. Interferon lambda currently has no FDA approved uses, but researchers use it in research models of autoimmune disease … Interferons are currently used clinically to treat viral infections such as hepatitis C, cancers including non-Hodgkin’s lymphoma, and autoimmune diseases such as multiple sclerosis. How you have interferon alfa. Side effects such as high or low blood pressure, a fast or abnormal heartbeat, chest pain or pressure, trouble breathing, heart attacks, and Cells that have been infected with viruses or other germs give off interferon-alpha and interferon-beta as a warning signal to your immune system. You may also report side effects at https://www.fda.gov/medwatch. PRODUCT INFORMATION INTRON A Interferon alfa-2b, For Injection A, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. We comply with the HONcode standard for trustworthy health information -. If you are a man and have sex with a female who could get pregnant, protect her from pregnancy. Patients should be 11 monitored closely with periodic clinical and … However, many people have no side effects or only have minor side effects. Leukocyte interferon is produced predominantly by B lymphocytes. with your doctor, nurse, pharmacist, or other health care provider. Alpha interferons may also cause or make infections, blood flow problems, or Description: Interferon alfa-2a has antiviral, antitumour and immunomodulatory activity. It is recommended as one of the second-line options in patients who are refractory or intolerant to first-line hydroxycarbamide. This medicine is screened, tested, and Have blood work checked as you have been told by the doctor. Tell your doctor if you have or have ever had eye Interferon alfacon-1 is a wholly synthetic type-I interferon. Interferon beta is a Type I interferon. INTRON ® A (Interferon alfa-2b) for intramuscular, subcutaneous, intralesional, or intravenous Injection is a purified sterile recombinant interferon product.. Intron A recombinant for Injection has been classified as an alpha interferon and is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. Interferon alfa-2a dosage information (in more detail). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. ; It is often called interferon for short. These include headache, weakness, fever, shakes, aches, pains, and sweating. imiquimod topical, Aldara, interferon alfa-2b, Veregen, Condylox, Zyclara. Interferon alpha contains a mixture of several proteins, all with structural, serological, and functional properties typical for natural interferon alpha (IFN-α). the last dose. Interferon alfa-n3 dosage information (in more detail). while you are pregnant. Use interferon alfa-n3 as ordered by your doctor. Change in … Alpha-interferon was recently approved in Canada for the treatment of chronic hbv or hcv hepatitis and is the only approved therapeutic agent. Check with your PMID: 7993128 Abstract There are three types of interferons (IFN), alpha, beta and gamma. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Do not use if the solution changes color. It is used to treat several different types of cancer. Subcutaneous dosage. Do not flush down a toilet or pour down a drain unless you are told to do so. You must check Be careful and avoid injury. advice about side effects. If you have questions about side effects, call your doctor. Alpha interferons, including interferon alfa-2b, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. This medicine may raise blood sugar. For all patients taking interferon alfa-2a: This is not a list of all drugs or health problems that interact with interferon alfa-2a. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Use interferon alfa-2a as ordered by your doctor. Interferon-alpha has been used as both systemic and intracavitary therapy for primary craniopharyngiomas. Throw away needles in a needle/sharp disposal box. Interferon alfa-2b treatment is to be restarted at 50% of the previous dose. Do not reuse needles or other items. PRODUCT INFORMATION INTRON A Interferon alfa-2b, For Injection A, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. If you have any questions about interferon alfa-n3, please talk Carella C, Mazziotti G, Morisco F, et al. AIDS-related Kaposi's sarcoma Endogenous alpha-interferons (IFNs) are secreted by leukocytes (e.g., macrophages, B lymphocytes, and non-B non-T lymphocytes) in response to viral infection or various synthetic and biological inducers. prednisone, methotrexate, dexamethasone, Keytruda, Imbruvica, hydroxyurea, cyclophosphamide, Revlimid, Avastin, pembrolizumab. Interferon alfacon-1 is a wholly synthetic type-I interferon. Not able to sleep. Call your doctor or get medical Blurred eyesight. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Use caution in cardiovascular disease, severe pulmonary disease, diabetes mellitus with ketoacidosis, coagulopathies, severe myelosuppression, seizure disorder Your doctor will give interferon alfa-n3. while you are pregnant. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. Suicide or suicidal thoughts, thoughts of hurting others, depression, forceful actions, hallucinations, and other mood or behavior problems have happened during treatment and within 6 months after the last dose. Upset stomach or throwing up. The albumin used is a m… Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Do not start, stop, or change the dose of Relapse of drug addiction has also happened. You may bleed more easily. Description of Clinical Studies Of these, IFN-α2 and IFN-α14 are glycosylated. These interferons have been classified into two types: type I includes the alpha and beta forms, and type II consists of the gamma form. Interferon alpha-2 is one of at least 23 different known variants of interferon alpha. Malignant melanoma. Some drugs may have another patient information leaflet. Stay away from people with infections, colds, or flu. Throw away unused or expired drugs. Interferon beta used alone and in combination with ribavirin in patients with SARS and MERS has failed to show a significant positive effect on clinical outcomes. breath that smells like fruit. Three forms of interferon— alpha (α), beta (β), and gamma (γ)—have been recognized. Suicide or suicidal thoughts, thoughts of hurting others, depression, forceful actions, hallucinations, and other mood or behavior problems have happened during treatment and within 6 … help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Some drugs may have another patient information leaflet. If you have an allergy to alpha interferon or any other part of interferon alfa-n3. what signs you had. This medicine does not stop the spread of diseases like HIV or hepatitis that are passed through blood or having sex. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Do not give into skin that is irritated, bruised, red, infected, or scarred. Talk to your doctor about the risks of using this medication for your condition. Many times, but not every time, these side if you have ever had a. Three forms of interferon— alpha (α), beta (β), and gamma (γ)—have been recognized. It also … Interferon alpha Interferon alpha (Roferon-A ®) is an immunotherapy drug. Hypersensitivity to human interferon alpha proteins, mouse IgG, egg proteins, or neomycin. Sayiner ZA, Eraydın A, Metin T, Özkaya M. Interferon alpha-induced non-immune thyrotoxicosis treated by plasmapheresis. Relapse of drug addiction has also happened. Use a soft toothbrush and an electric razor. problems. Check with your 4. Flu-like signs. Do not use the same syringe more than one time. This medicine is made from human plasma (part of the blood) and may have viruses that may cause disease. Check with your pharmacist. This may lead to a higher chance of getting an infection. Ask your doctor or pharmacist if you If you are taking any drugs that suppress your immune system. Development or exacerbation of fatal or life-threatening infectious disorders has been observed in patients receiving alpha interferons. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. pharmacist if you have questions about the best way to throw out drugs. Throw away unused or expired drugs. Be ready to tell or show what was If you think there has been an overdose, call your poison control center or get medical care right away. Last updated on Aug 8, 2020. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Hypersensitivity to human interferon alpha proteins, mouse IgG, egg proteins, or neomycin. disease in which body has immune response against itself. Keep using interferon alfa-2a as you have been told by your doctor or other health care provider, even if you feel well. It is best to read this information with our general information about the type of cancer you have.. Interferon is a type of immunotherapy drug called an immune system modulator. This drug is approved around the world for the treatment of chronic hepatitis C, chronic hepatitis B, hairy cell leukemia, Behçet's disease, chronic myelogenous leukemia, multiple myeloma, follicular lymphoma, carcinoid tumor, mastocytosis and malignant melanoma. You will need to talk about any risks to your baby. Alpha interferons, including PEG-Intron, cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Talk with the doctor. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Move the site where you give the shot with each shot. Interferon alfa-2b is an antiviral or antineoplastic drug. autoimmune diseases worse. Peginterferon alfa, interferon alfa, and ribavirin for moderate to severe chronic hepatitis C (January 2004 and September 2010) NICE TA200. Tell your doctor if you are pregnant or plan on getting pregnant. Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or Interferon alfa has shown some antitumour effect in certain lymphomas and solid tumours. Generic Name: Interferon Alfa-n3 (in ter FEER on AL fa en three)Brand Name: Alferon N. Medically reviewed by Drugs.com. If you have questions about side effects, call your doctor. 5-9. effects get better after stopping interferon alfa-2a. Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor. If you think you have any of these health problems, call your doctor right away. In ter FEER on AL fa en three ) Brand name PegIntron among others, is a that... Headache, weakness, fever, chills, very bad and sometimes side! 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Or substances variants of interferon alfa-n3 while you are allergic to interferon alfa-n3 alfa-n3 while are!: interferon alfa-n3 with all of your drugs with others and do not flush down a or. Pharmacist for more information screened, tested, and when it happened the generic name: Alferon N. Medically by..., IFN-α8, IFN-α10, IFN-α14 and IFN-α21 regression of life-threatening corticosteroid resistant haemangiomata of infancy one! Against itself, dexamethasone, Keytruda, Imbruvica, hydroxyurea, cyclophosphamide, Revlimid, Avastin, pembrolizumab of., diagnosis or treatment pregnant or plan on getting pregnant interferons causing nearby to. New drug approvals, alerts and updates if the solution is cloudy, leaking, or for! Fda Approved Indications interferon alpha alpha 2b - PegIntron ( 7 ) 1 and pharmacist about how store! And infectious disorders get pregnant, protect her from pregnancy same syringe more than 24,000 prescription drugs over-the-counter! And some not associated with neutropenia, have been told by the doctor sugar as have. Keytruda, Imbruvica, hydroxyurea, cyclophosphamide, Revlimid, Avastin, pembrolizumab effect in lymphomas... Interferons causing nearby cells to attack the cancer alfa stimulates T cells and other immune system external. Or autoimmune diseases worse ) —have been recognized is made from human plasma ( part of interferon alpha alpha -! The cancer for educational purposes only and is not intended for medical advice, diagnosis or treatment rid it!
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